alpha-Hydroxyglutaric acid
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(Redirected from 2-hydroxyglutarate)
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Names | |
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IUPAC name
2-Hydroxypentanedioic acid
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Other names
2-Hydroxyglutaric acid
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Identifiers | |
2889-31-8 ![]() |
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ChEBI | CHEBI:17084 ![]() |
ChemSpider | 42 ![]() |
Jmol 3D model | Interactive image Interactive image |
KEGG | C02630 ![]() |
MeSH | Alpha-hydroxyglutarate |
PubChem | 43 |
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Properties | |
C5H8O5 | |
Molar mass | 148.11 g·mol−1 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.
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