A-796,260
Systematic (IUPAC) name | |
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[1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
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Identifiers | |
CAS Number | 895155-26-7 |
PubChem | CID: 11584525 |
ChemSpider | 9759290 |
ChEMBL | CHEMBL262865 |
Chemical data | |
Formula | C22H30N2O2 |
Molecular mass | 354.485 g/mol |
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A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids with the 3-tetramethylcyclopropylmethanone group, imparts significant selectivity for CB2, and A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1.[1] It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.[2]
Legal Status
As of October 2015 A-796,260 is a controlled substance in China.[3]
See also
References
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- Chemical articles having calculated molecular weight overwritten
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- Drugs with no legal status
- Cannabinoids
- Cyclopropanes
- Aminoalkylindoles
- Tetramethylcyclopropanoylindoles
- Cannabinoid stubs