AM-1221
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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1-[(N-methylpiperidin-2-yl)methyl]-2-methyl-3-(naphthalen-1-oyl)-6-nitroindole
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Identifiers | |
CAS Number | 335160-53-7 |
PubChem | CID: 11604318 |
ChemSpider | 26286945 |
UNII | SHC6SNM293 |
Chemical data | |
Formula | C27H27N3O3 |
Molecular mass | 441.521 g/mol |
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AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor, giving it around 180x selectivity for CB2.[1] The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound AM-1241 is generally preferred for research purposes.[2][3]
See also
- AM-630
- AM-1220
- AM-1235
- AM-2233
- UR-144
- N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
References
- ↑ WO patent 200128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07
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- Cannabinoids
- Naphthoylindoles
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- Aminoalkylindoles
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- CB1 receptor agonists
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