ARNTL2

Aryl hydrocarbon receptor nuclear translocator-like 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KDK
Identifiers
Symbols	ARNTL2 ; BMAL2; CLIF; MOP9; PASD9; bHLHe6
External IDs	OMIM: 614517 MGI: 2684845 HomoloGene: 10609 GeneCards: ARNTL2 Gene
Gene ontology Molecular function • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein dimerization activity • E-box binding Cellular component • nucleus • transcription factor complex • nucleolus • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • circadian rhythm • entrainment of circadian clock • positive regulation of circadian rhythm • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56938	272322
Ensembl	ENSG00000029153	ENSMUSG00000040187
UniProt	Q8WYA1	Q2VPD4
RefSeq (mRNA)	NM_001248002	NM_001289679
RefSeq (protein)	NP_001234931	NP_001276608
Location (UCSC)	Chr 12: 27.33 – 27.43 Mb	Chr 6: 146.8 – 146.83 Mb
PubMed search	[1]	[2]

Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9, Bmal2, Clif, or Arntl2, is a gene.

Arntl2 is a paralog to Arntl, which are both homologs of the Drosophila Cycle. Homologs were also isolated in fish, birds and mammals such as mice and humans. Based on phylogenetic analyses, it was proposed that Arntl2 arose from duplication of the Arntl gene early in the vertebrate lineage, followed by rapid divergence of the Arntl gene copy. The protein product of the gene interacts with both CLOCK and NPAS2 to bind to E-box sequences in regulated promoters and activate their transcription. Although Arntl2 is not required for normal function of the mammalian circadian oscillator, it may play an important role in mediating the output of the circadian clock. Perhaps because of this, there is relatively little published literature on the role of Arntl2 in regulation of physiology.

Arntl2 is a candidate gene for human type 1 diabetes.

In over expression studies, ARNTL2 protein forms a heterodimer with CLOCK to regulate E-box sequences in the Pai-1 promoter. Recent work suggest that this interaction may be in concert with ARNTL/CLOCK heterodimeric complexes.

See also

• Arntl (Bmal1)

External links

• ARNTL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)