A disintegrin and metalloproteinase
From Infogalactic: the planetary knowledge core
ADAM (A Disintegrin And Metalloproteinase)[1][2] is a family of peptidase proteins.[3] It is also known as the adamalysin family or MDC family(metalloproteinase-like, Disintegrin-like, cysteine rich). ADAMs are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, activating it.[4] Therapeutic ADAM inhibitors can potentiate anti-cancer therapy.[citation needed]
It is categorized under EC 3.4.24.46.
ADAM
Family members are:
- ADAM2
- ADAM7
- ADAM8
- ADAM9
- ADAM10
- ADAM11
- ADAM12
- ADAM15
- ADAM17
- ADAM18 (=ADAM27)
- ADAM19
- ADAM20
- ADAM21 (=ADAM31)
- ADAM22
- ADAM23
- ADAM28
- ADAM29
- ADAM30
- ADAM33
Descriptions
ADAM Gene | Description |
---|---|
ADAM2 | ADAM2 is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[5] |
ADAM7 | ADAM7 is a transmembrane protein important for the maturation of sperm cells in mammals. ADAM7 is also denoted as: ADAM_7, ADAM-7, EAPI, GP-83, and GP83.[6] |
ADAM8 | The ADAM8 protein encoded by this gene may be involved in cell adhesion during neurodegeneration. |
ADAM9 | The ADAM9 protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.[8] |
ADAM10 | ADAM10 (EC#: 3.4.24.81) is a sheddase, and has a broad specificity for peptide hydrolysis reactions. [9] |
ADAM11 | The ADAM11 gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[10] |
ADAM12 | ADAM12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down syndrome marker.[11] |
ADAM15 | Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.[12] |
ADAM17 | ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network.
ADAM17 also has a role in the shedding of L-selectin, a cellular adhesion molecule.[13] |
ADAM18 | The protein encoded by this gene is a sperm surface protein.[14] |
ADAM19 | This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction.[15] |
ADAM22 | This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[16] |
ADAM23 | This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[17] |
ADAM28 | The protein encoded by this gene is a lymphocyte-expressed ADAM protein.[18] |
ADAM33 | This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.[19] |
References
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- ↑ Danforth's Obstetrics and Gynecology, 10th Edition; Copyright ©2008 Lippincott Williams & Wilkins; Chapter 7: Prenatal Diagnosis, Page 113
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See also
- ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) family
- Ectodomain shedding
External links
- ADAM Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
- http://www.healthvalue.net/sheddase.html
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