Adenine nucleotide translocator
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | |
|---|---|
| Identifiers | |
| Symbol | SLC25A4 |
| Alt. symbols | PEO3, PEO2, ANT1 |
| Entrez | 291 |
| HUGO | 10990 |
| OMIM | 103220 |
| RefSeq | NM_001151 |
| UniProt | P12235 |
| Other data | |
| Locus | Chr. 4 q35 |
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | |
|---|---|
| Identifiers | |
| Symbol | SLC25A5 |
| Alt. symbols | ANT2 |
| Entrez | 292 |
| HUGO | 10991 |
| OMIM | 300150 |
| RefSeq | NM_001152 |
| UniProt | P05141 |
| Other data | |
| Locus | Chr. X q24-q26 |
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | |
|---|---|
| Identifiers | |
| Symbol | SLC25A6 |
| Alt. symbols | ANT3 |
| Entrez | 293 |
| HUGO | 10992 |
| OMIM | 403000 |
| RefSeq | NM_001636 |
| UniProt | P12236 |
| Other data | |
| Locus | Chr. Y p |
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and imports ADP into the matrix.[1] ANT is the most plentiful protein in the inner mitochondrial membrane.[1]
Function
ANT has long been thought to function asymmetrically as a homodimer of subunits in the inner mitochondrial membrane. The dimer was thought to be a gated pore through which ADP and ATP were exchanged between the mitochondrial matrix and the cytoplasm. The dimer hypothesis was first challenged when the three-dimensional structure of ANT was discovered to be a monomer.[2] Further work has shown that ANT functions a monomer in detergents[3] and in mitochondrial membranes.[4][5]
ANT is an important structural component of the mitochondrial permeability transition pore[1][irrelevant citation] which can open and lead to cell death through apoptosis or necrosis.
Types
In humans, there exist three paraologous ANT isoforms:
- SLC25A4 – found primarily in heart and skeletal muscle
- SLC25A5 – primarily expressed in fibroblasts
- SLC25A6 – primarily express in liver
See also
Footnotes
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External links
- Adenine Nucleotide Translocator 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 3 at the US National Library of Medicine Medical Subject Headings (MeSH)
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