Altinicline

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Altinicline
Altinicline structure.png
Systematic (IUPAC) name
(2S)-3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine
Identifiers
CAS Number 179120-92-4 YesY
ATC code None
PubChem CID: 3036156
ChemSpider 2300234 YesY
UNII RJ9V9V09VM YesY
ChEMBL CHEMBL111659 YesY
Chemical data
Formula C12H14N2
Molecular mass 186.252
  • c2ncc(C#C)cc2C1CCCN1C
  • InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1 YesY
  • Key:NUPUDYKEEJNZRG-LBPRGKRZSA-N YesY
  (verify)

Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype.[1][2] It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models,[3] and progressed as far as Phase II clinical trials for Parkinson's disease,[4] although its current status is unclear.

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ The Parkinson Study Group. Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease. Neurology. 2006;66:408-410. doi:10.1212/01.wnl.0000196466.99381.5c


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