Apamea or Apameia (Greek: Απάμεια) was a Hellenistic city on the left (viz.,the east) bank of the Euphrates, opposite the famous city of Zeugma, at the end of a bridge of boats (Greek: zeugma) connecting the two, founded by Seleucus I Nicator (Pliny, v. 21). The city was rebuilt by Seleucus I. The site, once partially covered by the village of Tilmusa (formerly Rum-Kala), Şanlıurfa Province, Turkey, is now flooded by the lake formed by the Birecik Dam (Birejik Dam).  
- This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Apamea". Encyclopædia Britannica (11th ed.). Cambridge University Press.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- Smith, William (editor); Dictionary of Greek and Roman Geography, "Apameia", London, (1854)
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