Aspartylglucosaminidase

Aspartylglucosaminidase
250px PDB rendering based on 1apy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1APY, 1APZ
Identifiers
Symbols	AGA ; AGU; ASRG; GA
External IDs	OMIM: 613228 MGI: 104873 HomoloGene: 13 GeneCards: AGA Gene
EC number	3.5.1.26
Gene ontology Molecular function • N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity • peptidase activity • protein self-association Cellular component • extracellular space • lysosome • endoplasmic reticulum • extracellular exosome Biological process • proteolysis • protein deglycosylation • protein maturation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE AGA 204333 s at tn.png
File:PBB GE AGA 204332 s at tn.png
File:PBB GE AGA 216064 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	175	11593
Ensembl	ENSG00000038002	ENSMUSG00000031521
UniProt	P20933	Q64191
RefSeq (mRNA)	NM_000027	NM_001005847
RefSeq (protein)	NP_000018	NP_001005847
Location (UCSC)	Chr 4: 177.43 – 177.44 Mb	Chr 8: 53.51 – 53.52 Mb
PubMed search	[1]	[2]

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.

Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.

External links

• Aspartylglucosylaminase at the US National Library of Medicine Medical Subject Headings (MeSH)