BD1063

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BD1063
BD1063.png
Systematic (IUPAC) name
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine
Identifiers
CAS Number 150208-28-9
ChemSpider 499765
Chemical data
Formula C13H18Cl2N2
Molecular mass 273.20 g/mol
  • CN1CCN(CC1)CCc2ccc(c(c2)Cl)Cl
  • InChI=1S/C13H18Cl2N2/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11/h2-3,10H,4-9H2,1H3
  • Key:SUIZRDJCBVPASY-UHFFFAOYSA-N

BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor.[1]

Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.[1]

In other animal studies, BD1063 blocks the effects of MDMA,[2] and reduces alcohol intake in rodent models of alcoholism.[3]

See also

References

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