Beclamide

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Beclamide
Beclamide.svg
Systematic (IUPAC) name
N-benzyl-3-chloropropanamide
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number 501-68-8 YesY
ATC code N03AX30 (WHO)
PubChem CID: 10391
ChemSpider 9962 YesY
UNII F5N0ALI65V YesY
KEGG D07300 YesY
ChEMBL CHEMBL64195 YesY
Chemical data
Formula C10H12ClNO
Molecular mass 197.661 g/mol
  • ClCCC(=O)NCc1ccccc1
  • InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13) YesY
  • Key:JPYQFYIEOUVJDU-UHFFFAOYSA-N YesY
  (verify)

Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a drug that possesses anticonvulsant activity.[1]

Uses

It has been used as a sedative and as an anticonvulsant.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. It is no longer used as an AED.

Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.[2]

Side effects

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.

Administration and pharmacology

Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours. Beclamide is possibly metabolized to 3-chloropropanoic acid in vivo,[citation needed] which binds to the GHB receptor.

References

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  • The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.


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