Benzhydrocodone

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Benzhydrocodone.svg
Benzhydrocodone molecule ball.png
Systematic (IUPAC) name
6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-yl benzoate
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number 1259440-61-3
ChemSpider 31484780
Synonyms KP201
Chemical data
Formula C25H25NO4
Molecular mass 403.470
  • CN1CC[C@]23c4c5ccc(c4O[C@H]2C(=CC[C@H]3[C@H]1C5)OC(=O)c6ccccc6)OC
  • InChI=1S/C25H25NO4/c1-26-13-12-25-17-9-11-20(29-24(27)15-6-4-3-5-7-15)23(25)30-22-19(28-2)10-8-16(21(22)25)14-18(17)26/h3-8,10-11,17-18,23H,9,12-14H2,1-2H3/t17-,18+,23-,25-/m0/s1
  • Key:VPMRSLWWUXNYRY-PJCFOSJUSA-N

Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is a opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule.[1]

It is designed to be an opioid analgesic with a low chance of recreational use.[2]

Created by a biopharmaceutical company in Coralville, Iowa. President and CEO, Travis Mickle, believes the molecular-based approach to abuse-detterent may be more effective than many formulation-based approaches.[3]

References

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