|Sir Bernard Katz|
26 March 1911|
Leipzig, German Empire
|Died||20 April 2003
|Institutions||University College London
|Alma mater||University of Leipzig|
|Academic advisors||Archibald Hill|
|Known for||Neurophysiology of the synapse in 197|
|Spouse||Marguerite ("Rita") Penly Katz (d.1999) (2 children)|
Sir Bernard Katz, FRS (26 March 1911 – 20 April 2003) was a German-born biophysicist, noted for his work on nerve biochemistry. He shared the Nobel Prize in physiology or medicine in 1970 with Julius Axelrod and Ulf von Euler. He was knighted in 1970.
Life and career
Katz was born in Leipzig, Germany, to a Jewish family originally from Russia, the son of Eugenie (Rabinowitz) and Max Katz, a fur merchant. He was educated at the Albert Gymnasium in that city from 1921 to 1929 and went on to study medicine at the University of Leipzig. He graduated in 1934 and fled to Britain in February 1935, because the rise of Hitler made for a dangerous environment for Jews. He went to work at University College London, initially under the tutelage of Archibald Vivian Hill. He finished his PhD in 1938 and won a Carnegie Fellowship to study with John Carew Eccles at the Kanematsu Institute of Sydney Medical School. During this time, both he and Eccles gave research lectures at the University of Sydney. He was naturalised in 1941 and joined the Royal Australian Air Force in 1942. He spent the war in the Pacific as a radar officer. He married Marguerite Penly in 1945 and returned to UCL as an assistant director in 1946. Back in England he also worked with the 1963 Nobel prize winners Alan Hodgkin and Andrew Huxley. Katz was made a professor at UCL in 1952 and head of biophysics, he was elected a Fellow of the Royal Society (FRS) in 1952. He stayed as head of biophysics until 1978 when he became emeritus professor. He died in London on 20 April 2003, at the age of 92. He is survived by his two sons, David and Jonathan, the latter a former Master of The Queen's Scholars at Westminster School, and current stipendary lecturer at St Anne's College, Oxford.
His research uncovered fundamental properties of synapses, the junctions across which nerve cells signal to each other and to other types of cells. By the 1950s, he was studying the biochemistry and action of acetylcholine, a signalling molecule found in synapses linking motor neurons to muscles, used to stimulate contraction. Katz won the Nobel for his discovery with Paul Fatt that neurotransmitter release at synapses is "quantal", meaning that at any particular synapse, the amount of neurotransmitter released is never less than a certain amount, and if more is always an integral number times this amount. Scientists now understand that this circumstance arises because, prior to their release into the synaptic gap, transmitter molecules reside in like-sized subcellular packages known as synaptic vesicles, released in a similar way to any other vesicle during exocytosis.
Katz's work had immediate influence on the study of organophosphates and organochlorines, the basis of new post-war study for nerve agents and pesticides, as he determined that the complex enzyme cycle was easily disrupted.
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- "School of Katz" (PDF). Quarterly Journal of Experimental Biology. 1990.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- The Release of Neural Transmitter Substances (The Sherrington Lectures X), Charles C Thomas Publisher, Springfield (Illinois) 1969, pp. 60
- Sir Bernard Katz Biography. Nobel Foundation
- Guardian Obituary
- Australian Neuroscience Society Obituary
- Sabbatini, R.M.E.: Neurons and synapses. The history of its discovery IV. Chemical transmission. Brain & Mind, 2004.
- Physiology Online, PhysiologyNews, Issue 52, Autumn 2003
- Bernard Katz: "An autobiographical sketch"
- König-Albert-Gymnasium Leipzig