Brazilian hemorrhagic fever
| Sabiá virus | |
|---|---|
| Virus classification | |
| Group: |
Group V ((−)ssRNA)
|
| Family: | |
| Genus: | |
| Species | |
|
Sabiá virus |
|
Lua error in Module:Taxonbar/candidate at line 22: attempt to index field 'wikibase' (a nil value).
| Brazilian hemorrhagic fever | |
|---|---|
| Classification and external resources | |
| Specialty | Infectious disease |
| ICD-10 | A96.8 |
| Patient UK | Brazilian hemorrhagic fever |
Brazilian hemorrhagic fever (BzHF) is an infectious disease caused by the Sabiá virus, an Arenavirus.[1] The Sabiá virus is one of the arenoviruses from South America to cause hemorrhagic fever.[2] It shares a common progenitor with the Junin virus, Machupo virus, Tacaribe virus, and Guanarito virus.[2] It is an enveloped RNA virus and is highly infectious and lethal.[3] Very little is known about this disease, but it is thought to have be transmitted by the excreta of rodents.[1][3]
There have only been three documented infections of the Sabiá virus, only one of which occurred naturally and the other two cases occurred in the clinical setting.[1] The only naturally occurring case was in 1990, when a female agricultural engineer who was staying in the neighborhood of Jardim Sabiá near São Paulo, Brazil contracted the disease. She presented with hemorrhagic fever and died.[1] Her autopsy showed liver necrosis.[1] A virologist who was studying the woman's disease contracted the virus but survived.[1] Ribavirin was not given in these first two cases.[1] Four years later, in 1994, a researcher was exposed to the virus in a level 3 biohazard facility at Yale University when a centrifuge bottle cracked, leaked, and released aerosolized virus particle.[1][4] He was successfully treated with ribavirin.[1][5]
Ribavirin is thought to be effective in treating the illness, similar to other arenaviruses.[1][5] Compared to the patients who did not receive ribavirin, the patient who was treated with it had a shorter and less severe clinical course.[1] Symptomatic control such as fluids to address dehydration and bleeding may also be required.[5]
The Sabiá virus is a Biosafety Level 4 pathogen.[3]
This virus has also been implicated as a means for bioterrorism, as it can be spread through aerosols.[6]
See also
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 3.0 3.1 3.2 NRT Quick Reference Guide: Brazilian Hemorrhagic Fever (BzHF)
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 5.0 5.1 5.2 http://www.stanford.edu/group/virus/arena/2005/SabiaVirus.htm Sabia Virus
- ↑ http://www.oregon.gov/DHS/ph/acd/bioterrorism/backvhf.pdf Viral Hemorrhagic Fevers and Bioterrorism
