CDON

Cell adhesion associated, oncogene regulated
Rendering based on PDB 3D1M.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3D1M, 3N1F, 3N1Q
Identifiers
Symbols	CDON ; CDO; CDON1; HPE11; ORCAM
External IDs	OMIM: 608707 MGI: 1926387 HomoloGene: 22996 GeneCards: CDON Gene
Gene ontology Molecular function • protein binding Cellular component • plasma membrane • cell surface • integral component of membrane • extracellular matrix Biological process • cell fate specification • lens development in camera-type eye • cell adhesion • myoblast fusion • anterior/posterior pattern specification • embryonic body morphogenesis • skeletal muscle satellite cell differentiation • cerebral cortex development • muscle cell differentiation • positive regulation of MAPK cascade • regulation of protein heterodimerization activity • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of skeletal muscle tissue development • positive regulation of small GTPase mediated signal transduction • positive regulation of muscle cell differentiation • embryonic retina morphogenesis in camera-type eye • positive regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50937	57810
Ensembl	ENSG00000064309	ENSMUSG00000038119
UniProt	Q4KMG0	Q32MD9
RefSeq (mRNA)	NM_001243597	NM_021339
RefSeq (protein)	NP_001230526	NP_067314
Location (UCSC)	Chr 11: 125.96 – 126.06 Mb	Chr 9: 35.42 – 35.51 Mb
PubMed search	[1]	[2]

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]

Interactions

CDON has been shown to interact with CDH1 and BOC.