Capreomycin
File:Capreomycin IA.svg | |
File:Capreomycin IB.svg | |
Systematic (IUPAC) name | |
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(3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide
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Clinical data | |
AHFS/Drugs.com | monograph |
MedlinePlus | a682860 |
Pregnancy category |
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Routes of administration |
intramuscular |
Identifiers | |
CAS Number | 11003-38-6 |
ATC code | J04AB30 (WHO) |
PubChem | CID: 3000502 |
DrugBank | DB00314 |
ChemSpider | 2272094 |
UNII | 232HYX66HC |
KEGG | D00135 |
ChEMBL | CHEMBL2221250 |
NIAID ChemDB | 007653 |
Chemical data | |
Formula | C25H44N14O8 |
Molecular mass | 668.706 g/mol |
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Capreomycin is a antibiotic which is given in combination with other antibiotics for MDR-tuberculosis. Capreomycin is administered intramuscularly and shows bacteriostatic activity.[1]
Adverse effects include nephrotoxicity and 8th cranial auditory vestibular nerve nerve toxicity. The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. People on this medication should get hearing tests. It is commonly grouped with the aminoglycosides. It is a cyclic peptide.
Capreomycin was discovered in 1960, isolated from Streptomyces capreolus[2] It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.[3]
Spectrum of susceptibility
Capreomycin is frequently used to treat Mycobacterium tuberculosis infections. Mycobacterium tuberculosis growth has been found to be inhibited at a concentration of 2.5 μg/mL.[4]
References
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- ↑ http://www.toku-e.com/Assets/MIC/Capreomycin%20sulfate.pdf
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