Ciclazindol

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Ciclazindol
Ciclazindol structure.svg
Systematic (IUPAC) name
10-(3-chlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]indol-10-ol
Clinical data
Legal status
  •  ?
Routes of
administration
Oral
Pharmacokinetic data
Metabolism Renal[1]
Biological half-life ~32 hours[1]
Excretion Urine, feces[1]
Identifiers
CAS Number 37751-39-6
ATC code none
PubChem CID: 37825
ChemSpider 34683
UNII Y3I9520J7P YesY
KEGG D03486
ChEMBL CHEMBL1192491
Chemical data
Formula C17H15ClN2O
Molecular mass 298.77 g/mol

Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed.[2][3] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.[2][4] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor.[4][5][6] As suggested by its local anesthetic properties,[5] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[7][8]

See also

References

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  2. 2.0 2.1 Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  3. Levine S (1979). "A controlled comparative trial of a new antidepressant, ciclazindol". The Journal of International Medical Research. 7 (1): 1–6. PMID 369921.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. 4.0 4.1 Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  5. 5.0 5.1 Waterfall JF, Smith MA, Gaston WH, Maher J, Warburton G (July 1979). "Cardiovascular and autonomic actions of ciclazindol and tricyclic antidepressants". Archives Internationales de Pharmacodynamie et de Thérapie. 240 (1): 116–36. PMID 507990.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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  8. Lee K, Khan RN, Rowe IC, et al. (April 1996). "Ciclazindol inhibits ATP-sensitive K+ channels and stimulates insulin secretion in CR1-G1 insulin-secreting cells". Molecular Pharmacology. 49 (4): 715–20. PMID 8609901.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>