Clobutinol

Clobutinol

Systematic (IUPAC) name
(RS)-1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	Withdrawn (EU)
Routes of administration	oral
Identifiers
CAS Number	14860-49-2 Y
ATC code	R05DB03 (WHO)
PubChem	CID: 26937
DrugBank	DB09004 N
ChemSpider	25085 Y
UNII	1NY2IX043A Y
KEGG	D07716 Y
ChEMBL	CHEMBL1474889 N
Chemical data
Formula	C14H22ClNO
Molecular mass	255.783 g/mol
SMILES Clc1ccc(cc1)CC(O)(C)C(C)CN(C)C
InChI InChI=1S/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3 Y Key:KVHHQGIIZCJATJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval. Clobutinol was in 2007 determined to cause cardiac arrhythmia in some patients.

Boehringer Ingelheim products containing clobutinol were voluntarily withdrawn from sale in Germany, and the rest of the world, on August 31, 2007.

The approval for Germany and the EU was revoked in 2008.

See also

• QT interval
• Long QT syndrome