Corticotropin-like intermediate peptide
From Infogalactic: the planetary knowledge core
pro-opiomelanocortin | |
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Identifiers | |
Symbol | POMC |
Entrez | 5443 |
HUGO | 9201 |
OMIM | 176830 |
RefSeq | NM_000939 |
UniProt | P01189 |
Other data | |
Locus | Chr. 2 p23 |
Names | |
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IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
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Identifiers | |
53917-42-3 | |
ChemSpider | 14195066 |
PubChem | 16133227 |
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Properties | |
C112H165N27O36 | |
Molar mass | 2465.668 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally-occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Although it does not appear to play any particularly important roles in the body,[4] it does have some biological activity,[5][6] especially of the neurological variety.[7][8][9][10][11]
References
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External links
- Corticotropin-Like Intermediate Lobe Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Genes on human chromosome 2
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- Neuropeptides