Cytochrome c oxidase subunit II

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"COX2" redirects here. For the cyclooxygenase isoenzyme, see COX-2.

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Cytochrome c oxidase subunit II, transmembrane domain
File:1qle opm.png
Bacterial cytochrome c oxidase complex. Subunit II indicated by blue.
Identifiers
Symbol COX2_TM
Pfam PF02790
InterPro IPR011759
PROSITE PDOC00075
SCOP 1occ
SUPERFAMILY 1occ
TCDB 3.D.4
OPM superfamily 4
OPM protein 1v55
Cytochrome C oxidase subunit II, periplasmic domain
Identifiers
Symbol COX2
Pfam PF00116
InterPro IPR002429
PROSITE PDOC00075
SCOP 1occ
SUPERFAMILY 1occ
TCDB 3.D.4
OPM superfamily 4
OPM protein 1v55
CDD cd13912

Cytochrome c oxidase subunit 2, also known as cytochrome c oxidase polypeptide II, is a protein that in humans is encoded by the MT-CO2 gene.[1]

Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase.

Structure

Cytochrome c oxidase (EC 1.9.3.1)[2][3] is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). In Leigh's disease, there may be an abnormality or deficiency of cytochrome oxidase.

Function

Subunit 2 (COII) transfers the electrons from cytochrome c to the catalytic subunit 1. It contains two adjacent transmembrane regions in its N-terminus and the major part of the protein is exposed to the periplasmic or to the mitochondrial intermembrane space, respectively. COII provides the substrate-binding site and contains a copper centre called Cu(A) (see IPR001505), probably the primary acceptor in cytochrome c oxidase. An exception is the corresponding subunit of the cbb3-type oxidase which lacks the copper A redox-centre. Several bacterial COII have a C-terminal extension that contains a covalently bound haem c.

The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.

References

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Further reading

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