DPYS

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Dihydropyrimidinase
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DPYS ; DHP; DHPase
External IDs OMIM613326 MGI1928679 HomoloGene20359 ChEMBL: 2465 GeneCards: DPYS Gene
EC number 3.5.2.2
RNA expression pattern
File:PBB GE DPYS 206065 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1807 64705
Ensembl ENSG00000147647 ENSMUSG00000022304
UniProt Q14117 Q9EQF5
RefSeq (mRNA) NM_001385 NM_001164466
RefSeq (protein) NP_001376 NP_001157938
Location (UCSC) Chr 8:
104.33 – 104.47 Mb
Chr 15:
39.77 – 39.86 Mb
PubMed search [1] [2]

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.[1][2]

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
The image above contains clickable links
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: Lua error in package.lua at line 80: module 'strict' not found.


References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
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  • Lua error in package.lua at line 80: module 'strict' not found.

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