Decoglurant
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Systematic (IUPAC) name | |
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5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
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Clinical data | |
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Identifiers | |
CAS Number | 911115-16-7 |
ATC code | none |
PubChem | CID: 71533696 |
ChemSpider | 32695160 |
Chemical data | |
Formula | C21H11F6N5 |
Molecular mass | 447.336 g/mol |
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Decoglurant (INN) (code name RG1578, RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder.[1][2] Decoglurant progressed as far as phase II clinical trials[1][2] but was ultimately discontinued from further development due to disappointing efficacy results.[3][4]
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Categories:
- Chemical articles having calculated molecular weight overwritten
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- Abandoned drugs
- MGlu2 receptor antagonists
- MGlu3 receptor antagonists
- Nervous system drug stubs