DiFMDA

DiFMDA

Systematic (IUPAC) name
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)propan-2-amine
Clinical data
Legal status	CA: Schedule I UK: Class A
Identifiers
CAS Number	910393-51-0 N
ATC code	none
PubChem	CID: 57467735
ChemSpider	26495356
Chemical data
Formula	C10H11F2NO2
Molecular mass	215.076 g/mol
SMILES CC(Cc1ccc2c(c1)OC(O2)(F)F)N
InChI InChI=1S/C10H11F2NO2/c1-6(13)4-7-2-3-8-9(5-7)15-10(11,12)14-8/h2-3,5-6H,4,13H2,1H3 Key:BHDXKBALNFHXDV-UHFFFAOYSA-N
NY (what is this?)  (verify)

Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA. Since a major route of the normal metabolism of these compounds is scission of the methylenedioxy ring, producing neurotoxic metabolites such as alpha-methyldopamine, it was hoped that the difluoromethylenedioxy bioisostere would show increased metabolic stability and less toxicity.

These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and MDMA. However, there is known to be a lack of bulk tolerance at this position of the molecule, shown by the generally reduced activity of the ethylidenedioxy and isopropylidenedioxy analogues. It is also now generally accepted that MDMA neurotoxicity results from a variety of different causes and is not solely due to accumulation of alpha-methyldopamine, making it unclear how much less neurotoxic DFMDA and related drugs would be in practice.

See also

• 6-APB
• EIDA
• IAP
• MDAI