Dille–Koppanyi reagent
The Dille–Koppanyi reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.1 g of cobalt(II) acetate dihydrate dissolved in 100 ml of methanol mixed with 0.2 ml of glacial acetic acid. Part B made up of is 5% isopropylamine (v/v) in methanol.[1][2] Two drops of A are dropped onto the substance followed by one drop of B and any change in colour is observed.
The test turns phenobarbital, pentobarbital, amobarbital and secobarbital light purple[1] by complexation of cobalt with the barbiturate nitrogens.[3] The test, in a slightly different formulation, was developed in the 1930s by American pharmacologists Theodore Koppanyi and James M. Dille.[4][5]
See also
References
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External links
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