ESAT-6

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6 kDa early secretory antigenic target
Identifiers
Symbol esxA
Entrez 886209
PDB 3FAV
UniProt P0A564

ESAT-6, the 6 kDa early secretory antigenic target produced by Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen.[1] It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and TB7.7.

ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction.[2]

See also

References

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