Edgar Adrian

The Right Honourable The Lord Adrian OM PRS
President of the Royal Society
In office 1950–1955
Preceded by	Sir Robert Robinson
Succeeded by	Sir Cyril Norman Hinshelwood
Personal details
Born	(1889-11-30)30 November 1889 Hampstead, London, England
Died	Cambridge, Cambridgeshire
Nationality	United Kingdom
Spouse(s)	Hester Adrian (m. 1923)
Children	Anne Keynes Richard Adrian (1927–1995) Jennet Campbell (b. 1927)
Parents	Hume Chancellor Pinsent Ellen Pinsent
Scientific career
Fields	Biology (electrophysiology)
Alma mater	University of Cambridge
Notable awards	Fellow of the Royal Society Nobel Prize in Physiology or Medicine 1932 Royal Medal (1934) Copley Medal (1946) Albert Medal (1953)

Edgar Douglas Adrian, 1st Baron Adrian OM PRS (30 November 1889 – 4 August 1977) was an English electrophysiologist and recipient of the 1932 Nobel Prize for Physiology, won jointly with Sir Charles Sherrington for work on the function of neurons. He provided experimental evidence for the all-or-none law of nerves.

Biography

Adrian was born at Hampstead, London, to Alfred Douglas Adrian, legal adviser to the Local Government Board, and Flora Lavinia Barton. He attended Westminster School and studied Natural Sciences at Trinity College, Cambridge, graduating in 1911 and in 1913, he was elected to a Fellowship of Trinity College on account of his research into the "all or none" law of nerves.

After completing a medical degree in 1915, he did clinical work at St Bartholomew's Hospital London during World War I, treating soldiers with nerve damage and nervous disorders such as shell shock. Adrian returned to Cambridge as a lecturer and in 1925 began research on the human sensory organs by electrical methods.

Adrian married Hester Agnes Pinsent on 14 June 1923 and they had three offspring - a daughter and mixed twins:

• Anne Pinsent Adrian, who married the physiologist Richard Keynes
• Richard Hume Adrian, 2nd Baron Adrian (1927–1995)
• Jennet Adrian (b. 1927), who married Peter Watson Campbell.

Career

Continuing earlier studies of Keith Lucas, he used a capillary electrometer and cathode ray tube to amplify the signals produced by the nervous system and was able to record the electrical discharge of single nerve fibres under physical stimulus. An accidental discovery by Adrian in 1928 proved the presence of electricity within nerve cells. Adrian said,

"I had arranged electrodes on the optic nerve of a toad in connection with some experiments on the retina. The room was nearly dark and I was puzzled to hear repeated noises in the loudspeaker attached to the amplifier, noises indicating that a great deal of impulse activity was going on. It was not until I compared the noises with my own movements around the room that I realized I was in the field of vision of the toad's eye and that it was signaling what I was doing."

A key result, published in 1928, stated that the excitation of the skin under constant stimulus is initially strong but gradually decreases over time, whereas the sensory impulses passing along the nerves from the point of contact are constant in strength, yet are reduced in frequency over time, and the sensation in the brain diminishes as a result.

Extending these results to the study of pain causes by the stimulus of the nervous system, he made discoveries about the reception of such signals in the brain and spatial distribution of the sensory areas of the cerebral cortex in different animals. These conclusions lead to the idea of a sensory map, called the homunculus, in the somatosensory system.

Later, Adrian used the electroencephalogram to study the electrical activity of the brain in humans. His work on the abnormalities of the Berger rhythm paved the way for subsequent investigation in epilepsy and other cerebral pathologies. He spent the last portion of his research career investigating olfaction.

Positions that he held during his career included Foulerton Professor 1929–1937; Professor of Physiology in the University of Cambridge 1937–1951; President of the Royal Society 1950–1955; Master of Trinity College, Cambridge, 1951–1965; president of the Royal Society of Medicine 1960–1962; Chancellor of the University of Cambridge 1967–1975; Chancellor of the University of Leicester 1957–1971. Adrian was elected a Foreign Honorary Member of the American Academy of Arts and Sciences in 1938. In 1946 he became foreign member of the Royal Netherlands Academy of Arts and Sciences. In 1942 he was awarded membership to the Order of Merit and in 1955 was created Baron Adrian, of Cambridge in the County of Cambridge.

Bibliography

• The Basis of Sensation (1928)
• The Mechanism of Nervous Action (1932)
• Factors Determining Human Behavior (1937)

External links

• The Master of Trinity at Trinity College, Cambridge

Academic offices
Preceded by George Macaulay Trevelyan	Master of Trinity College, Cambridge 1951–1965	Succeeded by The Lord Butler of Saffron Walden
Preceded by New position	Chancellor of the University of Leicester 1957–1971	Succeeded by Alan Lloyd Hodgkin
Preceded by The Lord Tedder	Chancellor of the University of Cambridge 1967–1976	Succeeded by HRH The Duke of Edinburgh
Peerage of the United Kingdom
Preceded by New Creation	Baron Adrian 1955–1977	Succeeded by Richard Adrian