Etoperidone

Etoperidone

Systematic (IUPAC) name
2-[3-[4-(3-chlorophenyl)piperazin-1-yl] propyl]-4,5-diethyl-1,2,4-triazol-3-one
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	52942-31-1 Y
ATC code	N06AB09 (WHO)
PubChem	CID: 40589
ChemSpider	37083 Y
UNII	KAI6MVO39Z Y
ChEMBL	CHEMBL1743259 N
Synonyms	ST-1191
Chemical data
Formula	C19H28ClN5O
Molecular mass	377.911 g/mol
SMILES Clc3cccc(N2CCN(CCCN1/N=C(\N(C1=O)CC)CC)CC2)c3
InChI InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 Y Key:IZBNNCFOBMGTQX-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Etoperidone (Axiomin, Centren, Depracer, Etonin, Etoran, Staff, Tropene), also known as clopradone and triazolinone, is an antidepressant of the phenylpiperazine class which was introduced in Europe in 1977. It acts primarily as an antagonist of several receptors in the following order of potency: 5-HT_2A receptor (36 nM) > α₁-adrenergic receptor (38 nM) > 5-HT_1A receptor (85 nM) > α₂-adrenergic receptor (570 nM); it has only very weak or negligible affinity for blocking the following receptors: D₂ receptor (2,300 nM) > H₁ receptor (3,100 nM) > mACh receptors (>35,000 nM). In addition to its receptor blockade, etoperidone also has weak affinity for the monoamine transporters as well: serotonin transporter (890 nM) > norepinephrine transporter (20,000 nM) > dopamine transporter (52,000 nM).

See also

• Serotonin antagonist and reuptake inhibitor (SARI)