Etoxeridine

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Etoxeridine
Etoxeridine.svg
Systematic (IUPAC) name
ethyl 1-[2-(2-hydroxyethoxy)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
Legal status
Identifiers
CAS Number 469-82-9 YesY
ATC code none
PubChem CID: 61122
DrugBank DB01505 YesY
ChemSpider 55070 YesY
UNII RHW35E1G7E YesY
ChEMBL CHEMBL2104254
Synonyms Etoxeridine, Carbetidine, Atenos
Chemical data
Formula C18H27NO4
Molecular mass 321.41 g/mol
  • C1(CCN(CC1)CCOCCO)(C(=O)OCC)C2=CC=CC=C2
  • InChI=1S/C18H27NO4/c1-2-23-17(21)18(16-6-4-3-5-7-16)8-10-19(11-9-18)12-14-22-15-13-20/h3-7,20H,2,8-15H2,1H3 YesY
  • Key:KJTKYGFGPQSRRA-UHFFFAOYSA-N YesY
  (verify)

Etoxeridine (Carbetidine, Atenos) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).

Etoxeridine was developed in the 1950s[1] and investigated for use in surgical anesthesia, however it was never commercialised and is not currently used in medicine.[2][3][4]

References

  1. ↑ BE Patent 558883
  2. ↑ Merlevede E, Levis S. Pharmacological study of carbetidine, a new synthetic analgesic. (French). Archives Internationales de Pharmacodynamie et de Thérapie. 1958 May 1;115(1-2):213-32.
  3. ↑ Sironi PG. Brief note on a new synthetic analgesic: carbetidine hydrochloride. (Italian). Minerva Anestesiologica. 1959 Jun;25(6):251-4.
  4. ↑ Crawford JS, Foldes FF. Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia. British Journal of Anaesthesia. 1959 Aug;31:348-51.


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