Fenbufen

Fenbufen
Systematic (IUPAC) name
	4-(4-Biphenylyl)-4-oxobutanoic acid; or; 4-Oxo-4-(4-phenylphenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	POM;
Routes of; administration	Oral
Identifiers
CAS Number	36330-85-5
ATC code	M01AE05 (WHO)
PubChem	CID: 3335
DrugBank	DB08981
ChemSpider	3218
UNII	9815R1WR9B
KEGG	D01344
ChEBI	CHEBI:31599
ChEMBL	CHEMBL277522
Chemical data
Formula	C16H14O3
Molecular mass	254.2854
	SMILES O=C(O)CCC(=O)c2ccc(c1ccccc1)cc2 ;
	InChI InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19) ; Key:ZPAKPRAICRBAOD-UHFFFAOYSA-N ;
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Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.^[1]

It was introduced by American Cyanamid under the trade name Lederfen in the 1980s and was withdrawn from markets in the developed world due to liver toxicity in 2010.^[2]^[3]^{:370, 383-384}

As of 2015 it was available in Taiwan and Thailand under several brand names.^[4]

References

↑ Brogden RN. Non-steroidal anti-inflammatory analgesics other than salicylates. Drugs. 1986;32 Suppl 4:27-45. Review. PMID 3552584
↑ Monthly Index of Medical Specialities Deleted products 2010
↑ Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22 in Drug-Induced Liver Disease, 3rd Edition. Eds Neil Kaplowitz N and DeLeve LD. Academic Press, 2013 ISBN 9780123878182
↑ Drugs.com Drugs.com international listings for fenbufen Page accessed June 25, 2015

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[1] Brogden RN. Non-steroidal anti-inflammatory analgesics other than salicylates. Drugs. 1986;32 Suppl 4:27-45. Review. PMID 3552584

[2] Monthly Index of Medical Specialities Deleted products 2010

[3] Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22 in Drug-Induced Liver Disease, 3rd Edition. Eds Neil Kaplowitz N and DeLeve LD. Academic Press, 2013 ISBN 9780123878182

[4] Drugs.com Drugs.com international listings for fenbufen Page accessed June 25, 2015

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v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

Fenbufen

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Systematic (IUPAC) name


4-(4-Biphenylyl)-4-oxobutanoic acid or 4-Oxo-4-(4-phenylphenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	POM
Routes of administration	Oral
Identifiers
CAS Number	36330-85-5
ATC code	M01AE05 (WHO)
PubChem	CID: 3335
DrugBank	DB08981^Y
ChemSpider	3218^Y
UNII	9815R1WR9B^Y
KEGG	D01344^Y
ChEBI	CHEBI:31599^Y
ChEMBL	CHEMBL277522^Y
Chemical data
Formula	C₁₆H₁₄O₃
Molecular mass	254.2854
SMILES O=C(O)CCC(=O)c2ccc(c1ccccc1)cc2
InChI InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)^Y Key:ZPAKPRAICRBAOD-UHFFFAOYSA-N^Y

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