File:Dr Linda Buck ForMemRS.jpg
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Summary
Linda Buck’s research has transformed the field of odorant perception through the cloning of mammalian olfactory receptors. Together with Richard Axel, Buck developed an ingenious method to identify a G protein-coupled odorant receptor family of unprecedented size, comprising up to 1000 distinct genes members. Buck then used olfactory receptor genes as molecular tools to gain insight into the mechanisms and organisations strategies underlying odor perception. Her work showed that the olfactory epithelium is comprised of spatial zones that express different sets of receptor genes and that each zone is a mosaic of randomly interspersed neurons expressing different receptors. Buck then showed that individual olfactory neurons express a single receptor gene. In later work, Buck has documented the organization of olfactory axonal projections into the brain.
Buck’s work has been recognised by award of the 2004 Nobel Prize.
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| current | 00:47, 16 January 2017 | | 3,724 × 5,586 (7.18 MB) | 127.0.0.1 (talk) | Linda Buck’s research has transformed the field of odorant perception through the cloning of mammalian olfactory receptors. Together with Richard Axel, Buck developed an ingenious method to identify a G protein-coupled odorant receptor family of unprecedented size, comprising up to 1000 distinct genes members. Buck then used olfactory receptor genes as molecular tools to gain insight into the mechanisms and organisations strategies underlying odor perception. Her work showed that the olfactory epithelium is comprised of spatial zones that express different sets of receptor genes and that each zone is a mosaic of randomly interspersed neurons expressing different receptors. Buck then showed that individual olfactory neurons express a single receptor gene. In later work, Buck has documented the organization of olfactory axonal projections into the brain. <p>Buck’s work has been recognised by award of the 2004 Nobel Prize. </p> <table style="width:100%; clear:both; text-align:center; margin:0.5em auto; background-color:#f9f9f9; border:2px solid #e0e0e0; padding: 0; border-spacing: 8px;" class="layouttemplate licensetpl mw-content-ltr" lang="en"> <tr> <td style="width:90px;" rowspan="3"> <img alt="w:en:Creative Commons" src="https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/90px-CC_some_rights_reserved.svg.png" title="w:en:Creative Commons" width="90" height="36" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/135px-CC_some_rights_reserved.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/180px-CC_some_rights_reserved.svg.png 2x" data-file-width="744" data-file-height="300"><br><img alt="attribution" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/24px-Cc-by_new_white.svg.png" title="attribution" width="24" height="24" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/36px-Cc-by_new_white.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/48px-Cc-by_new_white.svg.png 2x" data-file-width="64" data-file-height="64"><img alt="share alike" src="https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/24px-Cc-sa_white.svg.png" title="share alike" width="24" height="24" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/36px-Cc-sa_white.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/48px-Cc-sa_white.svg.png 2x" data-file-width="64" data-file-height="64"> </td> <td lang="en"> This file is licensed under the <a href="https://en.wikipedia.org/wiki/en:Creative_Commons" class="extiw" title="w:en:Creative Commons">Creative Commons</a> <a rel="nofollow" class="external text" href="//creativecommons.org/licenses/by-sa/3.0/deed.en">Attribution-Share Alike 3.0 Unported</a> license. </td> <td style="width:90px;" rowspan="3"> </td> </tr> <tr style="text-align:center;"><td> <b>Attribution: <span style="font-size: larger;" class="licensetpl_attr">The Royal Society</span></b> </td></tr> <tr style="text-align:left;" lang="en"><td> <dl> <dd>You are free: <ul> <li> <b>to share</b> – to copy, distribute and transmit the work</li> <li> <b>to remix</b> – to adapt the work</li> </ul> </dd> <dd>Under the following conditions: <ul> <li> <b>attribution</b> – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).</li> <li> <b>share alike</b> – If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.</li> </ul> </dd> </dl> <p><span class="licensetpl_link" style="display:none;">http://creativecommons.org/licenses/by-sa/3.0 </span><span class="licensetpl_short" style="display:none;">CC BY-SA 3.0 </span><span class="licensetpl_long" style="display:none;">Creative Commons Attribution-Share Alike 3.0 </span><span class="licensetpl_link_req" style="display:none;">true</span><span class="licensetpl_attr_req" style="display:none;">true</span> </p> </td></tr> </table> <table class="messagebox layouttemplate" style="margin:0.3em 0;width:100%;direction:ltr"><tr> <td width="70"> <img alt="OTRS Wikimedia" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/70px-OTRS_Wikimedia.svg.png" title="OTRS Wikimedia" width="70" height="38" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/105px-OTRS_Wikimedia.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/140px-OTRS_Wikimedia.svg.png 2x" data-file-width="120" data-file-height="65"><p><span class="layouttemplateargs" style="display:none;speak:none;" title="template=PermissionOTRS 1%3Dhttps%3A%2F%2Fticket.wikimedia.org%2Fotrs%2Findex.pl%3FAction%3DAgentTicketZoom%26TicketNumber%3D2014062710019796 2%3D2014062710019796"> </span> </p> </td> <td> <span lang="en" class="description en">This work is <a href="http://freedomdefined.org/Definition" class="extiw" title="freedomdefined:Definition">free</a> and may be used by anyone for any purpose. 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