File:Professor Susan Lindquist ForMemRS.jpg
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Summary
Susan Lindquist has transformed our understanding of how protein folding shapes biological systems. She has made ground-breaking contributions in genetics, cell biology and biochemistry, using organisms as diverse as fungi, fruit flies, mustard plants, and mammals.
She discovered the functions of heat-shock proteins, identified prions as conduits of protein-based inheritance, and pioneered new platforms for neurodegenerative disease. She established the key role of the heat-shock proteins in tumor progression and the evolution of fungal drug resistance. She discovered that protein-folding buffers and releases genetic variation in response to environmental stress, providing the first plausible explanation for rapid bursts of evolution.
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| current | 07:04, 7 January 2017 | | 3,724 × 5,586 (10.38 MB) | 127.0.0.1 (talk) | Susan Lindquist has transformed our understanding of how protein folding shapes biological systems. She has made ground-breaking contributions in genetics, cell biology and biochemistry, using organisms as diverse as fungi, fruit flies, mustard plants, and mammals. <p>She discovered the functions of heat-shock proteins, identified prions as conduits of protein-based inheritance, and pioneered new platforms for neurodegenerative disease. She established the key role of the heat-shock proteins in tumor progression and the evolution of fungal drug resistance. She discovered that protein-folding buffers and releases genetic variation in response to environmental stress, providing the first plausible explanation for rapid bursts of evolution. </p> <table style="width:100%; clear:both; text-align:center; margin:0.5em auto; background-color:#f9f9f9; border:2px solid #e0e0e0; padding: 0; border-spacing: 8px;" class="layouttemplate licensetpl mw-content-ltr" lang="en"> <tr> <td style="width:90px;" rowspan="3"> <img alt="w:en:Creative Commons" src="https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/90px-CC_some_rights_reserved.svg.png" title="w:en:Creative Commons" width="90" height="36" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/135px-CC_some_rights_reserved.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/180px-CC_some_rights_reserved.svg.png 2x" data-file-width="744" data-file-height="300"><br><img alt="attribution" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/24px-Cc-by_new_white.svg.png" title="attribution" width="24" height="24" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/36px-Cc-by_new_white.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/48px-Cc-by_new_white.svg.png 2x" data-file-width="64" data-file-height="64"><img alt="share alike" src="https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/24px-Cc-sa_white.svg.png" title="share alike" width="24" height="24" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/36px-Cc-sa_white.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Cc-sa_white.svg/48px-Cc-sa_white.svg.png 2x" data-file-width="64" data-file-height="64"> </td> <td lang="en"> This file is licensed under the <a href="https://en.wikipedia.org/wiki/en:Creative_Commons" class="extiw" title="w:en:Creative Commons">Creative Commons</a> <a rel="nofollow" class="external text" href="//creativecommons.org/licenses/by-sa/3.0/deed.en">Attribution-Share Alike 3.0 Unported</a> license. </td> <td style="width:90px;" rowspan="3"> </td> </tr> <tr style="text-align:center;"><td> <b>Attribution: <span style="font-size: larger;" class="licensetpl_attr">The Royal Society</span></b> </td></tr> <tr style="text-align:left;" lang="en"><td> <dl> <dd>You are free: <ul> <li> <b>to share</b> – to copy, distribute and transmit the work</li> <li> <b>to remix</b> – to adapt the work</li> </ul> </dd> <dd>Under the following conditions: <ul> <li> <b>attribution</b> – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).</li> <li> <b>share alike</b> – If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.</li> </ul> </dd> </dl> <p><span class="licensetpl_link" style="display:none;">http://creativecommons.org/licenses/by-sa/3.0 </span><span class="licensetpl_short" style="display:none;">CC BY-SA 3.0 </span><span class="licensetpl_long" style="display:none;">Creative Commons Attribution-Share Alike 3.0 </span><span class="licensetpl_link_req" style="display:none;">true</span><span class="licensetpl_attr_req" style="display:none;">true</span> </p> </td></tr> </table> <table class="messagebox layouttemplate" style="margin:0.3em 0;width:100%;direction:ltr"><tr> <td width="70"> <img alt="OTRS Wikimedia" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/70px-OTRS_Wikimedia.svg.png" title="OTRS Wikimedia" width="70" height="38" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/105px-OTRS_Wikimedia.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1d/OTRS_Wikimedia.svg/140px-OTRS_Wikimedia.svg.png 2x" data-file-width="120" data-file-height="65"><p><span class="layouttemplateargs" style="display:none;speak:none;" title="template=PermissionOTRS 1%3Dhttps%3A%2F%2Fticket.wikimedia.org%2Fotrs%2Findex.pl%3FAction%3DAgentTicketZoom%26TicketNumber%3D2014062710019796 2%3D2014062710019796"> </span> </p> </td> <td> <span lang="en" class="description en">This work is <a href="http://freedomdefined.org/Definition" class="extiw" title="freedomdefined:Definition">free</a> and may be used by anyone for any purpose. 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