File:Splicing repression.jpg
Summary
Generalized model of splicing repression.
Splicing repressor proteins (mostly hnRNPs) bind to splicing silencers in exons (ESS) and introns (ISS). They inhibit the binding of U1 snRNP to the donor site, and of U2AFs and the U2 snRNP to the acceptor site and branch point. This results in skipping of the exon (yellow).
Information from: Black, Douglas L. (2003). "Mechanisms of alternative pre-messenger RNA splicing". Annual Reviews of Biochemistry 72 (1): 291-336.
Wang, Z; Burge, Cb (May 2008). "Splicing regulation: from a parts list of regulatory elements to an integrated splicing code" (Free full text). RNA (New York, N.Y.) 14 (5): 802–13. doi:10.1261/rna.876308. ISSN 1355-8382. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/18369186?dopt=Abstract">PMID 18369186</a>. PMC: 2327353.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 15:48, 15 January 2017 | | 906 × 363 (86 KB) | 127.0.0.1 (talk) | Generalized model of splicing repression. <p>Splicing repressor proteins (mostly hnRNPs) bind to splicing silencers in exons (ESS) and introns (ISS). They inhibit the binding of U1 snRNP to the donor site, and of U2AFs and the U2 snRNP to the acceptor site and branch point. This results in skipping of the exon (yellow). </p> <p>Information from: Black, Douglas L. (2003). "Mechanisms of alternative pre-messenger RNA splicing". Annual Reviews of Biochemistry 72 (1): 291-336. </p> Wang, Z; Burge, Cb (May 2008). "Splicing regulation: from a parts list of regulatory elements to an integrated splicing code" (Free full text). RNA (New York, N.Y.) 14 (5): 802–13. doi:10.1261/rna.876308. ISSN 1355-8382. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/18369186?dopt=Abstract">PMID 18369186</a>. PMC: 2327353. |
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