Fludiazepam

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Fludiazepam
Fludiazepam.svg
Fludiazepam ball-and-stick model.png
Systematic (IUPAC) name
7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Clinical data
Trade names Erispan (JP, TW)
AHFS/Drugs.com International Drug Names
Legal status
Routes of
administration		 Oral (tablets)
Pharmacokinetic data
Metabolism Hepatic
Excretion Renal
Identifiers
CAS Number 3900-31-0 YesY
ATC code N05BA17 (WHO)
PubChem CID: 3369
DrugBank DB01567 YesY
ChemSpider 3252 YesY
UNII 7F64A2K16Z YesY
KEGG D01354 YesY
ChEBI CHEBI:31618 YesY
ChEMBL CHEMBL13291 YesY
Chemical data
Formula C16H12ClFN2O
Molecular mass 302.7
  • O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1C
  • InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3 YesY
  • Key:ROYOYTLGDLIGBX-UHFFFAOYSA-N YesY
  (verify)

Fludiazepam, marketed under the brand name Erispan (エリスパン)[1][2] is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam,[3] originally developed by Hoffman-La Roche in the 1960s.[4] It is marketed in Japan and Taiwan in the form of 0.25 mg tablets, making it around 40x more potent than diazepam. It exerts its pharmacological properties via enhancement of GABAergic inhibition.[5] Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam.[6] It possesses anxiolytic,[7][8][9] anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties.[10]

As with all benzodiazepines, fludiazepam is used recreationally.[11]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ US Patent 3299053 -ARYL-JH-L,X-BENZODIAZEPIN-Z(LH)-ONES
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links


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