Fusobacterium
| Fusobacterium | |
|---|---|
 |
|
| Fusobacterium novum in liquid culture | |
Scientific classification  |
|
| Kingdom: | Bacteria |
| Phylum: | Fusobacteria |
| Order: | Fusobacteriales |
| Family: | Fusobacteriaceae |
| Genus: | Fusobacterium Knorr 1922 |
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Fusobacterium is a genus of anaerobic, Gram-negative bacteria, similar to Bacteroides. Individual cells are rod-shaped bacilli with pointed ends.[1] Strains of Fusobacterium cause several human diseases, including periodontal diseases, Lemierre's syndrome, and topical skin ulcers.
Although older sources state that Fusobacterium is part of the normal flora of the human oropharynx, the current consensus is that Fusobacterium should always be treated as a pathogen.[2] F. prausnitzii, a gut commensal associated with healthy patients, was moved out of Fusobacterium into its own genus, Faecalibacterium, in 2002.
Clinical relevance
In 2011, researchers discovered that Fusobacterium flourishes in colon cancer cells, and is often also associated with ulcerative colitis, although researchers have not determined if the organism actually causes these diseases or if it simply flourishes in the environment these diseases create.[3] The bacterium is a big anchor for biofilms.[4][5]
In contrast to Bacteroides spp., Fusobacterium has a potent lipopolysaccharide.
Clindamycin was the most active antibiotic against Fusobacterium species, followed by chloramphenicol, carbenicillin, and cefoperazone (which were about equally active) and then cefamandole.[6]
References
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- ↑ Donald Kaye, William Kobasa, Karen Kaye. (1980). "Susceptibilities of anaerobic bacteria to cefoperazone and other antibiotics". Antimicrobial Agents and Chemotherapy, June 1980, pp. 957-960.
External links
- Anaerobic Gram-Negative Bacilli chapter in Baron's Medical Microbiology (online at the NCBI bookshelf).
- Fusobacterium From MicrobeWiki, the student-edited microbiology resource
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