Geoffrey M. Cooper

Geoffrey M. Cooper is associate dean of the natural sciences and professor of biology at Boston University. He earned his Ph.D. at the University of Miami in 1973 and was a postdoctoral fellow with nobel laureate Howard Temin. His work includes cellular growth control, cancer, and signal transduction. More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control proliferation, differentiation, and survival of mammalian cells." He is also the author of the textbook "The Cell".

Publications

• Terragni J, Nayak G, Banerjee S, Medrano JL, Graham JR, Brennan JF, Sepulveda S, Cooper GM. 2011. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. J Biol Chem. Oct 21;286(42):36215-27.
• Terragni J*, Graham JR*, Adams KW, Schaffer ME, Tullai JW, Cooper GM. 2008. Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors. BMC Cell Biol. Jan 28;9:6
• Tullai JW, Schaffer ME, Mullenbrock S, Sholder G, Kasif S, Cooper GM. 2007. Immediate-early and delayed primary response genes are distinct in function and genomic architecture. J Biol Chem. Aug 17;282(33):23981-95.
• Adams, K.W., and Cooper, G.M. 2007. Rapid turnover of Mcl-1 couples translation to cell survival and apoptosis. J. Biol. Chem. 282:6192-6200.
• Tullai, J.W., Chen, J., Schaffer, M.E., Kamenetsky, E., Kasif, S. and Cooper, G.M. 2007. GSK-3b mediates repression of CREB target genes in quiescent cells. J. Biol. Chem. 282:9482-9491.
• Cooper, G.M. and Hausman, R. E. 2006. The Cell: A Molecular Approach 4th ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
• Gross, V.S., Hess, M., and Cooper, G.M. 2005. Mouse embryonic stem cells and preimplantation embryos require signaling through the phosphatidylinositol 3-kinase pathway to suppress apoptosis. Mol. Reprod. Dev. 70:324-332.
• Zilz, A. and Cooper, G.M. 2004. A binding site for germ cell nuclear factor within the c-mos regulatory sequences. Mol. Reprod. Dev. 67:55-64.
• Tullai, J.W., Schaffer, M.E., Mullenbrock, S., Kasif, S., and Cooper, G.M. 2004. Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and MEK/ERK signaling pathways. J. Biol. Chem. 279: 20167-20177.
• Pagon, Z., Volker, J., Cooper, G.M., and Hansen, U. 2003. Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746.
• Cooper, G.M. and Hausman, R.E. 2003. The Cell: A Molecular Approach 3rd ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
• Hartley, D. and Cooper, G.M. 2002. The role of mTOR in the degradation of IRS-1: regulation of PP2A activity. J. Cell. Biochem. 85:304-314.
• Pap, M., and Cooper, G.M. 2002. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3b pathway. Mol. Cell. Biol. 22:578-586.
• Cooper, G.M. 2000. The Cell: A Molecular Approach 2nd ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
• Hartley, D. and Cooper, G.M. 2000. Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925-16932.
• Lin, H., Jurk, M., Gulick, T., and Cooper, G.M. 1999. Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800.
• Erhardt, P., Schremser, E.J., and Cooper, G.M. 1999. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19:5308-5315.
• Pap, M., and Cooper, G.M. 1998. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 273:19929-19932.
• Cooper, G.M. 1997. The Cell: A Molecular Approach. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
• Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.A., Kaplan, D.R., and Greenberg, M.E. 1997. Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665.
• Erhardt, P., Tomaselli, K.J., and Cooper, G.M. 1997. Identification of the MDM2 oncoproteinas a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272:15049-15052.
• Lopes, U.G., Yao, R., and Cooper, G.M. 1997. p53-dependent induction of apoptosis by proteasome inhibitors. J. Biol. Chem. 272:12893-12896.
• Cooper, G.M. 1995. Oncogenes 2nd ed. Jones and Bartlett Publishers, Boston.
• Xu, W., and Cooper, G.M. 1995. Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes. Mol. Cell. Biol. 15:5369-5375.
• Yao, R., and Cooper, G.M. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.

See also

Geoffry M. Cooper's Lab Site