George Chaldakov
| George Chaldakov | |
|---|---|
George Chaldakov in 2006
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| Born | George Nikov Chaldakov 23 February 1940 Burgas, Bulgaria |
| Residence | Varna, Bulgaria |
| Citizenship | Bulgaria |
| Nationality | Bulgarian |
| Fields | Vascular Biology Adipobiology Neurobiology |
| Institutions | Medical University of Varna |
| Alma mater | Medical University of Varna (M.D.)(Ph.D.) |
| Known for | Homo obesus |
| Notable awards | Iuliu Hațieganu University of Medicine and Pharmacy (Doctor Honoris Causa) |
George Nikov Chaldakov (Bulgarian: Георги Ников Чалдъков) born February 23, 1940, in Burgas, Bulgaria, is a Bulgarian vascular biologist well known for his contributions in the study of secretory function of vascular smooth muscle cells, and the role of neurotrophins and perivascular adipose tissue in pathogenesis of atherosclerosis.[1] He published the first Bulgarian textbook of Cell Biology in 1996 and in 2005 founded the Bulgarian Society for Cell Biology.
In 1966 graduated as MD from Varna Institute of Medicine (since 1991, named Medical University of Varna), Varna, Bulgaria.[1] In 1983 obtained PhD degree in Vascular Biology, "Ultrastructural and cytopharmacological study of aging in vascular smooth muscle cells, with special reference to their secretory function".[2] Since 2007, Chaldakov is Professor Emeritus at Medical University of Varna, Bulgaria.[citation needed]
In the past 30 years Chaldakov was involved in an interdisciplinary research in the fields of vascular biology, adipobiology and neurobiology and is one of the pioneers establishing the novel concept of the secretory function/phenotype of the vascular smooth muscle cells and further delineating their role in atherogenesis. Chaldakov developed a complex tripartite model of atherogenesis in which are involved smooth muscle cells, immune cells, and perivascular adipose tissue communicating through secreted factors (e.g. neurotrophins, adipokines, cytokines).
Chaldakov is main editor and founder in 1991 of Biomedical Reviews, An International Journal of Cell Biology of Disease and organizer of Biomedical Forum, Annual Program of Continuing Medical Education held at Medical University of Varna, Bulgaria.
Innovations and substantial contributions to science
- Concept of the secretory function/phenotype of the vascular smooth muscle cell, as related to atherogenesis.[3][4][5]
- Tubulin/microtubule-targeted pharmacology for atherosclerosis.[6][7][8]
- Concept of the neurotrophins NGF and BDNF as metabotrophic factors (metabotrophins) in cardiometabolic biology/diseases.[9][10]
- Conceptualize the protein secretory products of adipose tissue cells as adipokines, also focusing on perivascular adipose tissue.[11][12][13]
- In 2006 introduced the term Homo obesus and is actively involved in popularizing the need of healthy lifestyle and dietary restriction: millions of people suffer and die from starvation in ill-developed and poor countries while in Western world and Europe people get overweight and die as a result of strokes or heart infarctions.[17][18]
References and notes
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