IFNAR1

Interferon (alpha, beta and omega) receptor 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3S98, 3SE3, 3SE4, 4PO6
Identifiers
Symbols	IFNAR1 ; AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
External IDs	OMIM: 107450 MGI: 107658 HomoloGene: 524 ChEMBL: 1887 GeneCards: IFNAR1 Gene
Gene ontology Molecular function • type I interferon receptor activity • protein binding Cellular component • intracellular • plasma membrane • integral component of plasma membrane Biological process • cell surface receptor signaling pathway • JAK-STAT cascade • response to virus • cytokine-mediated signaling pathway • positive regulation of interferon-beta production • positive regulation of interferon-gamma production • T cell activation • type I interferon biosynthetic process • positive regulation of transcription, DNA-templated • positive regulation of interleukin-1 beta secretion • regulation of peptidyl-tyrosine phosphorylation • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3454	15975
Ensembl	ENSG00000142166	ENSMUSG00000022967
UniProt	P17181	P33896
RefSeq (mRNA)	NM_000629	NM_010508
RefSeq (protein)	NP_000620	NP_034638
Location (UCSC)	Chr 21: 33.32 – 33.36 Mb	Chr 16: 91.49 – 91.51 Mb
PubMed search	[1]	[2]

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

Interactions

IFNAR1 has been shown to interact with:

• PRMT1,
• STAT2, and
• Tyrosine kinase 2.