ADX-71149

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ADX-71149
Systematic (IUPAC) name
1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone
Identifiers
CAS Number 1127498-03-6
ATC code None
PubChem CID: 11523023
ChemSpider 9697810
Chemical data
Formula C19H15ClFNO2
Molecular mass 343.779 g/mol
  • COC1=CC=C(C=C1)C2=CN(C(=O)C=C2)CC3=C(C=C(C=C3)Cl)F
  • InChI=1S/C19H15ClFNO2/c1-24-17-7-3-13(4-8-17)14-5-9-19(23)22(11-14)12-15-2-6-16(20)10-18(15)21/h2-11H,12H2,1H3
  • Key:VLTLVMNNIVBONY-UHFFFAOYSA-N

ADX-71149, also known as JNJ-4041183 and JNJ-mGluR2-PAM, is a selective positive allosteric modulator of the mGlu2 receptor.[1][2][3] It is being studied by Addex Therapeutics and Janssen Pharmaceuticals for the treatment of schizophrenia.[4] It was also researched by these companies for the treatment of anxious depression (major depressive disorder with anxiety symptoms),[5] but although some efficacy was observed in clinical trials, it was not enough to warrant further development for this indication.[6] As of 2015, ADX-71149 is in phase II clinical trials for schizophrenia.[4]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links



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