JWH-210

From Infogalactic: the planetary knowledge core
(Redirected from JWH-182)
Jump to: navigation, search
JWH-210
JWH-210 structure.png
Systematic (IUPAC) name
4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
Clinical data
Legal status
  • DE: Anlage II (Prohibited)
  • Illegal in Sweden,I-N(Poland)[1]
Identifiers
CAS Number 824959-81-1 YesY (JWH-210)
Template:CAS (JWH-182)
PubChem CID: 45270396
ChemSpider 24617616
Chemical data
Formula C26H27NO
Molecular mass 369.498 g/mol
  • c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC
  • InChI=1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3
  • Key:LACIUQLUNACUKC-UHFFFAOYSA-N
  (verify)

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM).[2] It was discovered by and named after Dr. John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.[3]

Legal Status

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.[4][5] The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.[6]

As of October 2015 JWH-210 is a controlled substance in China.[7]

See also

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Swedish Code of Statutes Regulation (2010:1086).
  5. Swedish Code of Statutes Regulation (2010:1086). (pdf)
  6. LVFS 2011:8
  7. Lua error in package.lua at line 80: module 'strict' not found.


<templatestyles src="Asbox/styles.css"></templatestyles>

de:JWH-210