JWH-198

JWH-198

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Systematic (IUPAC) name
(1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methoxynaphthalen-1-ylmethanone
Clinical data
Legal status	CA: Schedule II
Identifiers
CAS Number	166599-76-4 N
PubChem	CID: 10319620
ChemSpider	8495084 N
Chemical data
Formula	C26H26N2O3
Molecular mass	414.495 g/mol
SMILES C4COCCN4CCn2cc(c5ccccc25)C(=O)c3c1ccccc1c(OC)cc3
InChI InChI=1S/C26H26N2O3/c1-30-25-11-10-22(19-6-2-3-8-21(19)25)26(29)23-18-28(24-9-5-4-7-20(23)24)13-12-27-14-16-31-17-15-27/h2-11,18H,12-17H2,1H3 N Key:QWHSUXWDDKWTOG-UHFFFAOYSA-N N
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JWH-198 is a drug from the aminoalkylindole family which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB₁ receptor of 10nM, binding around four times more tightly than the parent compound JWH-200, which has no substitution on the naphthoyl ring. It has been used mainly in molecular modelling of the cannabinoid receptors.

See also

• JWH-081
• JWH-193