Kaolin clotting time
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Kaolin clotting time (KCT) is a sensitive test to detect lupus anticoagulants.[1] There is evidence that suggests it is the most sensitive test for detecting lupus anticoagulants.[2] It can detect factor VIII inhibitors but is sensitive to unfractionated heparin.[3]
History
KCT was first described by Dr. Margolis in 1958.[4]
Principle
KCT is similar to the activated partial thromboplastin time test, except it does not use exogenous phospholipid.[1] Thus, a confirmatory test that uses excess phospholipid is needed to validate the presence of lupus anticoagulants.[1]
Kaolin is the surface activator, and the test also requires small amounts of cell fragments and plasma lipids to provide the phospholipid surface required for coagulation.[1][3] Therefore, the sample quality is important for the validity of the test.[1]
Method
The test combines a test plasma with kaolin, and the time the clot (in seconds) is measured.[4]
Interpretation
If the KCT is less than 60 seconds, this suggests that the normal control plasma is contaminated with platelet fragments; therefore, the test is not valid.[3]
The KCT test/control ratio of greater than or equal to 1.2 indicates an inhibitor is present.[3] If the test/control ratio is between 1.1 and 1.2, the test is equivocal.[3]
See also
References
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- ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
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