Keratin 14

Keratin 14, type I
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3TNU
Identifiers
Symbols	KRT14 ; CK14; EBS3; EBS4; K14; NFJ
External IDs	OMIM: 148066 MGI: 96688 HomoloGene: 110439 GeneCards: KRT14 Gene
Gene ontology Molecular function • structural constituent of cytoskeleton • protein binding • keratin filament binding Cellular component • nucleus • cytoplasm • cytosol • intermediate filament • keratin filament • extracellular exosome • cell periphery Biological process • aging • epidermis development • response to zinc ion • response to ionizing radiation • epithelial cell differentiation • hemidesmosome assembly • cell junction assembly • hair cycle • intermediate filament bundle assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3861	16664
Ensembl	ENSG00000186847	ENSMUSG00000045545
UniProt	P02533	Q61781
RefSeq (mRNA)	NM_000526	NM_016958
RefSeq (protein)	NP_000517	NP_058654
Location (UCSC)	Chr 17: 41.58 – 41.59 Mb	Chr 11: 100.2 – 100.21 Mb
PubMed search	[1]	[2]

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.

Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.

Pathology

Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and Dermatopathia pigmentosa reticularis, both of which are autosomal dominant mutations.

See also

• 34βE12 (keratin 903)

External links

• GeneReviews/NCBI/UW/NIH entry on Epidermolysis Bullosa Simplex
• Proteopedia page on keratins