Keratin 16

Keratin 16, type I
Keratin 16, type I
Identifiers
Symbols	KRT16 ; CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK; PC1
External IDs	OMIM: 148067 MGI: 96690 HomoloGene: 21145 GeneCards: KRT16 Gene
Gene ontology
Molecular function	• structural constituent of cytoskeleton; • protein binding;
Cellular component	• nucleus; • cytoskeleton; • intermediate filament; • extracellular exosome;
Biological process	• morphogenesis of an epithelium; • inflammatory response; • cytoskeleton organization; • aging; • cell proliferation; • epidermis development; • keratinocyte differentiation; • negative regulation of cell migration; • keratinization; • hair cycle; • innate immune response; • intermediate filament cytoskeleton organization; • keratinocyte migration; • establishment of skin barrier;
	Sources: Amigo / QuickGO
Orthologs
Species	Human
Entrez	3868
Ensembl	ENSG00000186832
UniProt	P08779
RefSeq (mRNA)	NM_005557
RefSeq (protein)	NP_005548
Location (UCSC)	Chr 17:; 41.61 – 41.62 Mb
PubMed search	[1]
	v; t; e;

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.^[1]^[2]^[3]

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.^[4]

External links

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