Keratin 18

Keratin 18, type I
Identifiers
Symbols	KRT18 ; CK-18; CYK18; K18
External IDs	OMIM: 148070 MGI: 96692 HomoloGene: 55448 GeneCards: KRT18 Gene
Gene ontology Molecular function • structural molecule activity • protein binding • poly(A) RNA binding • scaffold protein binding Cellular component • nucleolus • cytoplasm • microtubule organizing center • intermediate filament • centriolar satellite • keratin filament • perinuclear region of cytoplasm • extracellular exosome • cell periphery Biological process • cell cycle • anatomical structure morphogenesis • viral process • tumor necrosis factor-mediated signaling pathway • Golgi to plasma membrane CFTR protein transport • negative regulation of apoptotic process • intermediate filament cytoskeleton organization • extrinsic apoptotic signaling pathway • hepatocyte apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE KRT18 201596 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3875	16668
Ensembl	ENSG00000111057	ENSMUSG00000023043
UniProt	P05783	P05784
RefSeq (mRNA)	NM_000224	NM_010664
RefSeq (protein)	NP_000215	NP_034794
Location (UCSC)	Chr 12: 52.95 – 52.95 Mb	Chr 15: 102.03 – 102.03 Mb
PubMed search	[1]	[2]

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Interactions

Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1, DNAJB6, Pinin and TRADD.