Keratin 2A

Keratin 2, type II
Keratin 2, type II
Identifiers
Symbols	KRT2 ; CK-2e; K2e; KRT2A; KRT2E; KRTE
External IDs	OMIM: 600194 MGI: 96699 HomoloGene: 30974 GeneCards: KRT2 Gene
Gene ontology
Molecular function	• structural constituent of cytoskeleton; • protein binding;
Cellular component	• extracellular space; • nucleus; • cytoplasm; • Golgi apparatus; • intermediate filament; • membrane; • keratin filament; • intermediate filament cytoskeleton; • extracellular exosome;
Biological process	• epidermis development; • keratinization; • keratinocyte activation; • keratinocyte proliferation; • keratinocyte migration;
	Sources: Amigo / QuickGO
Orthologs
Species	Human
Entrez	3849
Ensembl	ENSG00000172867
UniProt	P35908
RefSeq (mRNA)	NM_000423
RefSeq (protein)	NP_000414
Location (UCSC)	Chr 12:; 52.64 – 52.65 Mb
PubMed search	[1]
	v; t; e;

Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.^[1]^[2]

Keratin 2A is a type II cytokeratin. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.^[3]

References

Keratin-2 at the US National Library of Medicine Medical Subject Headings (MeSH)

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