Kyotorphin

Kyotorphin

Names
IUPAC name (2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5- (diaminomethylideneamino)pentanoic acid
Other names Kiotorphin L-Tyrosyl-L-arginine
Identifiers
CAS Number	70904-56-2 N
ChEBI	CHEBI:17537 Y
ChEMBL	ChEMBL273521 Y
ChemSpider	110353 Y
Jmol 3D model	Interactive image
PubChem	123804
InChI InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1 Y Key: JXNRXNCCROJZFB-RYUDHWBXSA-N Y InChI=1/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1 Key: JXNRXNCCROJZFB-RYUDHWBXBC
SMILES O=C(O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)CCC/N=C(\N)N
Properties
Chemical formula	C15H23N5O4
Molar mass	337.38 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979. Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that its concentration is lower in patients with persistent pain.