Lymphocyte function-associated antigen 1
Lymphocyte function-associated antigen 1, also known as LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor and/or the cytokine receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate. LFA-1/ICAM-1 interaction has recently been shown to be important for T cell-T cell interactions, leading to further T cell differentiation.[citation needed]
LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). LFA-1 also has a distinct α-chain (αL, CD11a).[citation needed]
LFA-1 has also been found in a soluble form.[1]
See also
Further reading
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
- Parham, Peter, The Immune System 3rd ed. (2009) Garland Science: London and New York
References
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External links
- LFA-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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- ITGAL ITGB2 Info with links in the Cell Migration Gateway
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