Litoxetine

Litoxetine

Systematic (IUPAC) name
4-(naphthalen-2-ylmethoxy)piperidine
Identifiers
CAS Number	86811-09-8
ATC code	none
PubChem	CID: 65650
ChemSpider	59087
UNII	9980ST005G Y
ChEMBL	CHEMBL471036
Chemical data
Formula	C16H19NO
Molecular mass	241.327 g/mol
SMILES C3CNCCC3OCc2cc1ccccc1cc2

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s. It acts as a serotonin reuptake inhibitor and 5-HT₃ receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis. Development of litoxetine for medicinal use was apparently halted in the late 1990s.