Malakoplakia

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Malakoplakia
225px
Micrograph showing the characteristic finding of malakoplakia (Michaelis–Gutmann bodies). H&E stain.
Classification and external resources
Specialty Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value).
DiseasesDB 29128
eMedicine derm/872
Patient UK Malakoplakia
MeSH D008287
Orphanet 556
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]

Malakoplakia or Malacoplakia: Latin Malako meaning; soft, Plako meaning; plaque, is a rare inflammatory condition which makes its presence known as a papule, plaque or ulceration that usually affects the genitourinary tract.[1]:274 However, it may also be associated with other bodily organs. It was initially described in the early 20th century as soft yellowish plaques found on the mucosa of the urinary bladder. Microscopically it is characterized by the presence of foamy histiocytes with basophilic inclusions called Michaelis–Gutmann bodies.

It usually involves gram negative bacteria.[2]

Causes

Malakoplakia is thought to result from the insufficient killing of bacteria by macrophages. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium. The impairment of bactericidal activity manifests itself as the formation of an ulcer, plaque or papule.

Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma, diabetes mellitus, renal transplantation, or because of long-term therapy with systemic corticosteroids.

Treatment

Today, antibiotics are used for treatment of malakoplakia.

See also

References

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