Neurotensin receptor
From Infogalactic: the planetary knowledge core
| neurotensin receptor 1 (high affinity) | |
|---|---|
| Identifiers | |
| Symbol | NTSR1 |
| Alt. symbols | NTR |
| Entrez | 4923 |
| HUGO | 8039 |
| OMIM | 162651 |
| RefSeq | NM_002531 |
| UniProt | P30989 |
| Other data | |
| Locus | Chr. 20 q13-20q13 |
| neurotensin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | NTSR2 |
| Alt. symbols | NTR2 |
| Entrez | 23620 |
| HUGO | 8040 |
| OMIM | 605538 |
| RefSeq | NM_012344 |
| UniProt | O95665 |
| Other data | |
| Locus | Chr. 2 p25.1 |
| sortilin 1 | |
|---|---|
| Identifiers | |
| Symbol | SORT1 |
| Alt. symbols | Gp95, NT3 |
| Entrez | 6272 |
| HUGO | 11186 |
| OMIM | 602458 |
| RefSeq | NM_002959 |
| UniProt | Q99523 |
| Other data | |
| Locus | Chr. 1 p21.3-1p13.1 |
The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin.[1][2] Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.
Contents
Ligands
Agonists
- Peptide
- Beta-lactotensin (NTS2)[3]
- JMV-449
- Neurotensin
- Neuromedin N (NTS1 selective)
- PD-149,163 (NTS1 selective, reduced amide bond 8-13 fragment of neurotensin)
- Non-peptide
- Partial agonists derived from SR-48692[4]
Antagonists
- Levocabastine (NTS2 selective, also H1 histamine antagonist)[5]
- SR-48692 (NTS1 selective)[6]
- SR-142,948 (unselective, CAS# 184162-64-9)
Biophysical Investigation
Unusually for GPCRs, NTS1 can be expressed in an active form in the bacteria E. coli.[7] It can be purified and analysed in vitro and has been analysed by a number of biophysical techniques such as surface plasmon resonance,[8] FRET[9] and cryo-electron microscopy.[10]
References
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External links
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- Neurotensin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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